process chemistry 예문

• Once the compound entered pre-clinical development, process chemistry developed a cost-effective and scalable synthesis.
• Maryanoff emphasizes that accomplishments in process chemistry depend upon the work of teams of people who are involved in the research . antiepileptics,
• The products are for use in different applications, such as process chemistry, discovery chemistry, crystallization, and other chemistry related applications.
• Most large pharmaceutical process chemistry and manufacturing divisions have devised weighted quantitative schemes to measure the overall attractiveness of a given synthetic route over another.
• Green chemistry overlaps with all subdisciplines of chemistry but with a particular focus on chemical synthesis, process chemistry, and chemical engineering, in industrial applications.
• Content covers organic, medicinal, synthetic, agro, fine, catalyst, inorganic and process chemistry and provides information on structures, reactions, and citations.
• Recently, it has added dedicated process chemistry R & D to develop niche, limited competition and complex API s to enable corresponding formulation development and capitalize the opportunities.
• Merck s process chemistry department contracted Codexis, a medium-sized biocatalysis firm, to develop a large-scale biocatalytic reductive amination for the final step of its sitagliptin synthesis.
• One of the most prominent uses of biocatalysis in process chemistry today is in the synthesis of Januvia? a DPP-4 inhibitor developed by Merck for the management of type II diabetes.
• Because of this limitation, the process chemistry route toward LY500307 necessarily involved a kinetically controlled crystallization step after the hydrogenation to upgrade the enantiopurity of this penultimate intermediate to > 99 percent ee.
• On the other hand, Microsaic Systems in Surrey, United Kingdom develops single quadrupole mass spectrometer called 3500 and 4000 MiD . These mass analyzers are used for supporting the pharmaceutical process chemistry.
• Additionally, the process chemistry team envisioned a S N Ar strategy to install the quinoline heterocycle, instead of the S N 2 strategy that they had employed for the synthesis of BILN 2061.
• In nowadays it is an integrated solution provider, from process chemistry to particle engineering to formulation, from very small scale to full commercial capacity and from preclinical to lean, scale-up science, modeling.
• A wide variety of proprietary and increasingly complex variations of all these anodizing processes continue to be developed by industry, so the growing trend in military and industrial standards is to classify by coating properties rather than by process chemistry.
• Finally since a total synthesis project will often span a variety of reactions, it serves to prepare chemists for pursuits in process chemistry, where encyclopedic knowledge of chemical reactions and a strong and accurate sense of chemical intuition are necessary.
• The process chemistry team at Eli Lilly successfully developed a fully continuous process to this penultimate intermediate, including reaction, workup and kinetically controlled crystallization modules ( the engineering considerations implicit in these efforts are beyond the scope of this article ).
• Beginning in the early 2000s ( decade ) though process chemistry began emerging as a distinct field of synthetic chemistry focused on scaling up chemical synthesis to industrial levels, as well as finding ways to make these processes more efficient, safer, and environmentally responsible.
• In the medicinal chemistry specialty areas associated with the design and synthesis of chemical libraries or the execution of process chemistry aimed at viable commercial syntheses ( areas generally with fewer opportunities ), training paths are often much more varied ( e . g ., including focused training in physical organic chemistry, library-related syntheses, etc . ).
• A case study of particular interest involves the development of a fully continuous process by the process chemistry group at Eli Lilly and Company for an asymmetric hydrogenation to access a key intermediate in the synthesis of LY500307, a potent ER? agonist that is entering clinical trials for the treatment of patients with schizophrenia, in addition to a regimen of standard antipsychotic medications.
• "' Physical organic chemistry "', a term coined by Louis Hammett in 1940, refers to a discipline of organic chemistry that focuses on the relationship between chemical structures and polymer and supramolecular chemistry, and bioorganic chemistry, enzymology, and chemical biology, as well as to commercial enterprises involving process chemistry, chemical engineering, materials science and nanotechnology, and drug discovery.